Key Areas of Research
Research Areas
JuLaDQ aimed primarily but not exclusively undertake research on:
• Evaluation of pharmaceutical regulatory approval process in resource-limited economies;
• Evaluation of pharmaceutical quality and information content of different essential drugs in Ethiopia;
• Development and validation of QC methods for pre-formulation and formulated drug products;
• Establishment of rational specifications for unidentified, not yet toxicity/efficacy characterized impurities, as well as develop QC methods;
• Development of in-vivo relevant dissolution systems for selected neglected-disease medicines;
• Clinical trials and efficacy studies for medicines of infectious and non-infectious diseases;
• Assessment of indigenous knowledge towards treatment of tropical and infectious diseases with endogenous herbal medicine;
• Bio-functionality evaluation of endemic plants of Ethiopia against different tropical and infectious diseases and Natural product researches: bioassay, isolation and characterizations.
Research Activities
Research Projects (Ongoing):
1. BOF-UGent and JU PhD Project: Ivermectin subcutaneous MDA in cattle as a complementary tool together with LLINs and IRS for malaria control in One Health approach: an impact assessment study.
2. S-DISCO and NASCERE PhD Project: Sustainable removal of anthelmintics as emerging environmental contaminants of high concern.
3. BOF-UGent PhD Project: Development of artemisinin-derived medicines to improve stability and pharmacokinetic properties
4. JU – Mega Research Fund (MRF) Project: Antimicrobial Resistance Containment: Pharmaceutical Approaches in the Context of One Health Perspectives
Research Projects (Completed):
1. PhD Project: Ethnomedicinal Plants for Infectious Diseases in Ethiopia: Traditional Use, Antimicrobial & Antibiotic Modulating Effects, Phytochemistry, and Regulatory Perspectives. Sileshi Dubale (PhD) – successfully defended on 22nd August 2024 – funded by YaBiNaPA – Jimma University
2. PhD Project: Endectocide treatment of cattle as complementary tool for malaria control in sub–Saharan Africa; Gemechu Zeleke (PhD) – successfully defended on 16th January 2024 – funded by BOF-UGent Belgium
3. Antenna Foundation (Geneva, Switzerland) Argemone mexicana project (2020 – 2022): Argemone mexicana decoction as adjunct intervention for prevention of malaria in Ethiopia: a randomized controlled trial – Antenna Foundation (Geneva, Switzerland) funded project.
4. WHO Ethics and COVID-19 Project (2021 – 2022): Ethical challenges and considerations in the rationing of health commodities and provision of high-risk clinical services in resource-limited settings: Adjusting conventional pillars of medical ethics to guide services during COVID-19 pandemic – WHO-funded Project.
5. JU COVID-19 Project (2021 – 2022): BCG vaccination and TB exposure (latent TB infection) – Do they help the fight against COVID-19? – funded by Jimma University (JU) COVID-19 Special Grant
6. PhD Project: Functional quality of selected antimalarial and anthelminthic medicines; Sileshi Belew (PhD) – successfully defended on 25th November 2020 – funded by BOF-UGent Belgium
7. JU – LMU Khat Project (2016 – 2018): Khat alkaloids evaluation with a focus on nor-ephedrine project, funded by University of Konstaz and University of Munich/Germany.
8. VLIR – IUC/Network Drug Quality and therapeutics subproject (2013 – 2018): Evaluation of pharmaceutical regulatory approval process in Ethiopia – funded by VLIR-IUC/Network JU-UGent.
9. VLIR – IUC Drug Quality and therapeutics subproject (2009 – 2016): Establishment of rational specifications for unidentified, not yet toxicity/efficacy characterized impurities, as well as develop QC methods – funded by VLIR-IUC/JU-UGent.
10. MebendazolGAI3003 clinical trial project (2014 -2016): A Double-Blind, Randomized, Multi-Center, Parallel-Group, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Dose of a 500-mg Chewable Tablet of Mebendazole in the Treatment of Soil-Transmitted Helminth Infections (Ascaris Lumbricoides and Trichuris Trichiura) in Pediatric Subjects – funded by Johnson-Johnson Pharmaceuticals.
11. Insecticide residue analysis project (2014 – 2015): Determination of the residual efficacy of carbamate and organophosphate insecticides used for indoor residual spraying for malaria control in Ethiopia – funded by USAID AIRS-Ethiopia
JU Laboratory of Drug Quality |