Publication 2020-2022
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy
Background: Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false-negative tests and are a threat for malaria control.
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Burden of malaria, impact of interventions and climate variability in Western Ethiopia: an area with large irrigation based farming
Background: Land use change has increasingly been expanding throughout the world in the past decades. It can have profound effects on the spatial and temporal distribution of vector borne diseases like malaria through ecological and habitat....
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Urogenital schistosomiasis prevalence and diagnostic performance of urine filtration and urinalysis reagent strip in schoolchildren, Ethiopia
Background: Urogenital schistosomiasis has been known to be endemic in several lowland areas of Ethiopia. It is caused by Schistosoma haematobium and causes considerable public health problems to schoolchildren. Ethiopia, after mapping the distribution of the disease...... Read More
2022
Impact of ivermectin mass drug administration on burden of soil-transmitted helminths in onchocerciasis control and elimination programs, Yeki district, southwest Ethiopia
Background: Community-directed treatment with ivermectin (CDTi) is the primary strategy employed to control and eliminate human onchocerciasis in Ethiopia. After long-term mass distribution for onchocerciasis, ivermectin is expected to have additional...
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Composition of mosquito fauna and insecticide resistance status of Anopheles gambiae sensu lato in Itang special district, Gambella, Southwestern Ethiopia
Background: Anopheles arabiensis, member species of the Anopheles gambiae complex, is the primary vector of malaria and is widely distributed in Ethiopia. Anopheles funestus, Anopheles pharoensis and Anopheles nili are secondary vectors occurring......
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Enhancing malaria research, surveillance, and control in endemic areas of Kenya and Ethiopia
Background: Malaria control programs in Africa encounter daunting challenges that hinder progressive steps toward elimination of the disease. These challenges include widespread insecticide resistance in mosquito vectors, increasing outdoor malaria transmission,.....
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Evidence of pyrethroid resistance in Anopheles amharicus and Anopheles arabiensis from Arjo-Didessa irrigation scheme, Ethiopia
Background: Indoor residual spraying and insecticide-treated nets are among the key malaria control intervention tools. However, their efficacy is declining due to the development and spread.....
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Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia
Background: Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases in 2021 and 61% of the population living in areas at risk of malaria transmission. Throughout the country Plasmodium vivax.....
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Residual efficacy of SumiShield™ 50WG for indoor residual spraying in Ethiopia
Background: The rate of decay of the biological efficacy of insecticides used for indoor residual spraying (IRS) is an important factor when making decisions on insecticide choice for national malaria control programmes. A key roadblock to IRS programme is insecticide resistance......
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Emerging Evidence on Tenebrio molitor Immunity: A Focus on Gene Expression Involved in Microbial Infection for Host-Pathogen Interaction Studies
Background: In recent years, the scientific community’s interest in T. molitor as an insect model to investigate immunity and host-pathogen interactions has considerably increased. The reasons for this growing interest could be explained by the peculiar features.....
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Characterization of Anopheles mosquito larval habitats and species composition in Bambasi District, Northwestern Ethiopia
Background: Malaria is a widespread vector-borne disease in the tropics and subtropics causing nearly half a million deaths every year. Malaria vector control intervention mainly rely on the control of adults using Indoor residual sprayings (IRS) and......
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Assessing potential intermediate host snails of urogenital schistosomiasis, human water contact behavior and water physico-chemical characteristics in Alwero Dam Reservoir …
Background: Urogenital schistosomiasis is one of public health problems in lowland areas of Ethiopia. The disease is caused by Schistosoma haematobium. Freshwater Bulinus snails are intermediate hosts for the parasite transmission.......
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Habitat preference of blackflies in Omo Gibe river basin (southwest Ethiopia): Implications for onchocerciasis elimination and control…
Background: Ecological control of blackflies (Simulium damnosum) can be an alternative or additional tool to enhance onchocerciasis elimination efforts. However, limited research is conducted on the ecology of blackflies in Ethiopia......
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Low density Plasmodium infections and G6PD deficiency among malaria suspected febrile individuals in Ethiopia
Background: The identification and management of low parasitemia infections have become increasingly challenging for malaria control and elimination. Submicroscopic Plasmodium infections and G6PD deficiency among febrile patients require more sensitive diagnostic ......
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Evaluation of mass treatment with ivermectin program reach and survey coverage for onchocerciasis elimination in selected endemic areas of Ethiopia
Background: Currently, national governments of onchocerciasis endemic African countries are working towards the elimination of the disease using mass drug administration (MDA)....
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An experimental hut study evaluating the impact of pyrethroid-only and PBO nets alone and in combination with pirimiphos-methyl-based IRS in Ethiopial…
Background: Pyrethroid resistance observed in populations of malaria vectors is widespread in Ethiopia and could potentially compromise the effectiveness of insecticide-based malaria vector control interventions.......
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From Genes to Biomarkers: Understanding the biology of malaria gametocytes and their detection
Background: Each year, approximately 230 million malaria cases and 400, 00 malaria deaths are reported worldwide. Malaria is a life-threatening disease caused by Plasmodium parasites that are transmitted from one individual.......
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Drawings as tools to (re) imagine space in interdisciplinary global health research
Background: Understanding the role of space in infectious diseases' dynamics in urban contexts is key to developing effective mitigation strategies. Urbanism, a discipline that both studies and acts upon the city, commonly uses drawings......
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Impact of environmental modifications on the ecology, epidemiology, and pathogenesis of Plasmodium falciparum and Plasmodium vivax malaria in East Africa
Background: Food insecurity, recurrent famine, and poverty threaten the health of millions of African residents. Construction of dams and rural irrigation schemes is key to solving these problems. The sub-Saharan Africa.......
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Active case detection and treatment of malaria in pregnancy using LAMP technology (LAMPREG): a pragmatic randomised diagnostic outcomes trial—study protocol
Background: In 2017 about 219 million cases of malaria occurred worldwide and approximately 435,000 people died of the disease globally according to the World Health Organization. The sub-Saharan region experienced around 92% of these deaths .......
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Susceptibility of the Anopheles coustani complex to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia
Background: Insecticide-based vector control interventions along with case management with artemisinin-based combination therapy (ACT) reduced malaria incidence and prevalence worldwide. The current control methods focus on the primary malaria vector, Anopheles gambiae sl, however, the role of secondary ......
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Residual efficacy of SumiShield
Background: The rate of decay of the biological efficacy of insecticides used for indoor residual spraying (IRS) is an important factor when making decisions on insecticide choice for national malaria control programmes. A key roadblock to IRS programme is insecticide resistance.......
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Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia
Background: Insecticide-based vector control interventions in combination with case management with artemisinin-based combination therapy has reduced malaria incidence and prevalence worldwide........
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An update on the distribution, bionomics, and insecticide susceptibility of Anopheles stephensi in Ethiopia, 2018–2020
Background: Anopheles stephensi, an invasive malaria vector, was first detected in Africa nearly 10 years ago. After the initial finding in Djibouti, it has subsequently been found in Ethiopia, Sudan and Somalia. To better inform policies .........
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Effects of rainfall, temperature and topography on malaria incidence in elimination targeted district of Ethiopia
Background: Climate and environmental factors could be one of the primary factors that drive malaria transmission and it remains to challenge the malaria elimination efforts. Hence, this study was aimed to evaluate the effects of meteorological factors .......
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Entomological and anthropological factors contributing to persistent malaria transmission in Kenya, Ethiopia, and Cameroon
Background: In order to improve our understanding of the fundamental limits of core interventions and guide efforts based on prioritization and identification of effective/novel interventions with great .......
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Patterns of human exposure to early evening and outdoor biting mosquitoes and residual malaria transmission in Ethiopia
Background: Ethiopia has shown a notable progress in reducing malaria burden over the past decade, mainly due to the scaleup of vector control interventions such as long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS).........
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The effect of irrigation on malaria vector bionomics and transmission intensity in western Ethiopia
Background: Irrigation schemes may result in subsequent changes in malaria disease dynamics. Understanding the mechanisms and effects of irrigation on malaria vector bionomics and transmission intensity is essential to develop new or alternative.......
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Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa
Background: Plasmodium vivax malaria was thought to be rare in Africans who lack the Duffy blood group antigen expression. However, recent studies indicate that P. vivax can infect ......
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A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia
Background: The development of insecticide resistance in malaria vectors is of increasing concern in Ethiopia because of its potential implications for vector control failure. To better elucidate the specificity of resistance mechanisms and to facilitate the design of control strategies that minimize the likelihood .........
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Bio-Control of Anopheles Mosquito Larvae Using Invertebrate Predators to Support Human Health Programs in Ethiopia
Background: Mosquitoes have been a nuisance and health threat to humans for centuries due to their ability to transmit different infectious diseases. Biological control methods have emerged.......
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Anopheles arabiensis hotspots along intermittent rivers drive malaria dynamics in semi-arid areas of Central Ethiopia
Background: Understanding malaria vector’s population dynamics and their spatial distribution is important to define when and where the largest infection risks occur and implement appropriate control strategies In this study, the seasonal spatio-temporal dynamics .......
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Plasmodium vivax From Duffy-Negative and Duffy-Positive Individuals Share Similar Gene Pools in East Africa
Background: Plasmodium vivax malaria was thought to be rare in Africa, but an increasing number of P. vivax cases reported across Africa and in Duffy-negative individuals challenges this dogma. The genetic characteristics of P. vivax in Duffy-negative .........
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Predicting distribution of malaria vector larval habitats in Ethiopia by integrating distributed hydrologic modeling with remotely sensed data
Background: Larval source management has gained renewed interest as a malaria control strategy in Africa but the widespread and transient nature of larval breeding sites poses a challenge to its implementation........
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The pan African vivax and ovale network (PAVON): Refocusing on Plasmodium vivax, ovale and asymptomatic malaria in sub-Saharan Africa
Background: The recent World Malaria report shows that progress in malaria elimination has stalled. Current data acquisition by NMCPs depend on passive case detection and clinical reports focused mainly on Plasmodium falciparum (Pf). .......
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Malaria vector dynamics and utilization of insecticide-treated nets in low-transmission setting in Southwest Ethiopia: implications for residual transmission
Background: Understanding the behaviour of local malaria vectors is essential as effectiveness of the commonly used vector-targeted malaria control tools heavily relies on behaviour of the major malaria vectors. This study was conducted to determine species composition, biting behaviour, host preference and infectivity of anopheline mosquitoes, and assess utilization.........
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Efficacy and safety of artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia: a systematic review and meta-analysis
Background: Regular monitoring of anti-malarial drug efficacy is vital for establishing rational malaria treatment guidelines and ensuring adequate treatment outcomes. This study aimed to synthesize the available evidence on the efficacy of artemether–lumefantrine ........
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Hepatoprotective Effect of Corm of Ensete ventricosum (Welw.) Cheesman Extract against Isoniazid and Rifampicin Induced Hepatotoxicity in Swiss Albino Mice
Background: Drug‐induced liver injury (DILI) is one of the cumbersome health‐related problems which render approximately 50% of liver failure and patients to receiving liver transplantation every year. Antituberculosis drugs such as isoniazid and rifampicin.......
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Survivorship of Anopheles gambiae sensu lato in irrigated sugarcane plantation scheme in Ethiopia
Background: To ensure food security, sub-Saharan Africa has initiated massive water resource development projects, such as irrigated agriculture, in recent years. However, such environmental modifications affect the survivorship and development of mosquitoes, .........
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Species composition, blood meal sources and insecticide susceptibility status of Culex mosquitoes from Jimma area, Ethiopia
Background: Different species of Culex mosquitoes are present in high numbers in many other countries in addition to sub-Saharan Africa and Asian countries. Culex mosquitoes are serious nuisance........
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Malaria in migrant agricultural workers in western Ethiopia: entomological assessment of malaria transmission risk
Background: Ethiopia has made great strides in malaria control over the last two decades. However, this progress has not been uniform and one concern has been reported high rates of malaria transmission in large agricultural development areas in western Ethiopia. Improved vector control is one way this transmission .......
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Mesocosm experiments to quantify predation of mosquito larvae by aquatic predators to determine potential of ecological control of malaria vectors in Ethiopia
Background: Malaria parasites are transmitted to humans by infectious female Anopheles mosquitoes. Chemical-insecticide-based mosquito control has been successful in reducing the burden of malaria. However, the emergence of insecticide resistance in malaria .........
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Plasmodium falciparum hrp2 and hrp3 gene deletion status in Africa and South America by highly sensitive and specific digital PCR
Background: The most commonly used Plasmodium falciparum rapid diagnostic tests target the Histidine-Rich Proteins 2 and 3 (HRP2, HRP3). An increasing number of countries report parasites that carry hrp2 and/or hrp3 gene deletions, resulting in false negative test results Molecular surveillance .........
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Evaluation of Long-Lasting Insecticidal Nets (DuraNet®) Under laboratory and Semi-Field Conditions Using Experimental Huts Against Anopheles Mosquitoes in …
Background: Long-Lasting Insecticidal Nets (LLINs) efficacy could be compromised due to a lot of influences together with user compliance and vector population insecticide resistance status. Thus, this study was to assess the biological efficacy.......
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Species composition, spatio-temporal variation and habitat characterization of Anopheline larvae in Bure district, Northwestern Ethiopia
Background: In Ethiopia, mosquito larva control interventions are given less emphasis due to a number of factors including lack of precise information on potential breeding habitats and complicated vector biology. .........
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A whole transcriptomic approach reveals novel mechanisms of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia
Background: The development of insecticide resistance in malaria vectors is of increasing concern in Ethiopia because of its potential implications for vector control failure. To better elucidate the specificity of resistance mechanisms and to facilitate the design of control strategies that minimize .........
Read More2021
Efficacy and Safety of Artemether-Lumefantrine for Treatment of Uncomplicated P. Falciparum malaria in Ethiopia: A Systematic Review and Meta-Analysis
Background: Anti-malarial drug resistance, in particular resistance to Plasmodium falciparum, challenges the treatment and control of malaria. In Ethiopia, the rst-line treatment of uncomplicated falciparum malaria........
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Mosquito Species Composition And Insecticide Resistance Status of Anopheles Arabiensis In Itang Special Woreda, Gambella, Southwestern Ethiopia
Background: Anopheles arabiensis, member species of the Anopheles gambiae complex, is the primary vector of malaria widely distributed in Ethiopia. Anopheles funestus, An. pharoensis and An. nili are secondary vectors occurring with limited distribution in the country Indoor residual spraying (IRS) and long-lasting insecticidalnets (LLINs) are pillars ..........
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Prediction of Malaria Vector Larval Habitat Distribution and Transmission in Ethiopia by Integrating Distributed Hydrologic Modeling with Remotely Sensed Data
Background: Larval source management (LSM) has so far not been widely used in malaria vector control in Africa, partly due to the lack of understanding of the hydrological mechanism of aquatic habitat formulation and stability. LSM would be greatly facilitated if larval habitat distribution .........
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DETERMINATION OF MALARIA EXPOSURE IN ETHIOPIAN COMMUNITIES AND ITS RELATIONSHIP TO PLASMODIUM VIVAX MALARIAL BURDEN IN DUFFY-NEGATIVE INDIVIDUALS
Background: Anti-malarial drug resistance, in particular resistance to Plasmodium falciparum, challenges the treatment and control of malaria. In Ethiopia, the rst-line treatment........
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FIRST REPORT OF HIGH SURVIVAL AND FECUNDITY RATES OF MALARIA VECTOR MOSQUITOES IN IRRIGATED AREAS OF ETHIOPIA
Background: This research likely reports a significant finding: high survival and fecundity rates of malaria-carrying mosquitoes in irrigated areas of Ethiopia. This suggests that irrigation practices may inadvertently create favorable breeding sites for mosquitoes, leading to increased malaria transmission. ...........
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Composition of Mosquito Fauna and Insecticide Resistance Status of Anopheles gambiae complex in Itang special woreda, Gambella, Southwestern Ethiopia
Background: Malaria is a leading cause of morbidity and mortality mainly in sub-Saharan African countries. Plasmodium falciparum and P. vivax are the dominant malaria parasites responsible for the majority of malaria cases in Africa. .........
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Research Article Hepatoprotective Effect of Corm of Ensete ventricosum (Welw.) Cheesman Extract against Isoniazid and Rifampicin Induced Hepatotoxicity in Swiss Albino Mice
Background: Drug-induced liver injury (DILI) is one of the cumbersome health-related problems which render approximately 50% of liver failure and patients to receiving liver transplantation every year. Antituberculosis drugs.........
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Effects of environmental modification on the diversity and positivity of anopheline mosquito aquatic habitats at Arjo-Dedessa irrigation development site, Southwest Ethiopia
Background: Irrigated agriculture is key to increase agricultural productivity and ensure food security in Africa. However, unintended negative public health impacts (e.g. malaria) of such environmental modification have been a challenge............
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Impact of sugarcane irrigation on malaria vector Anopheles mosquito fauna, abundance and seasonality in Arjo-Didessa, Ethiopia
Background: Despite extensive irrigation development in Ethiopia, limited studies assessed the impact of irrigation on malaria vector mosquito composition, abundance and seasonality. This study aimed to evaluate the impact of sugarcane irrigation.........
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Analysis of trends of malaria from 2010 to 2017 in Boricha District, Southern Ethiopia
Background: Ethiopia has made a significant progress of malaria control. Currently, the country has adopted and is implementing the World Health Organization very ambitious, but achievable, malaria elimination plan through extensive efforts. The regular evaluation of its performance is vitall..........
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Evaluation of human-baited double net trap and human-odour-baited CDC light trap for outdoor host-seeking malaria vector surveillance in Kenya and Ethiopia
Background: Surveillance of outdoor host-seeking malaria vectors is crucial to monitor changes in vector biting behaviour and evaluate the impact of vector control interventions. Human landing catch (HLC)............
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Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes
Background: Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans are Duffy negative. .........
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Species diversity and distribution of Anopheles mosquitoes in Bure district, Northwestern Ethiopia
Background: Malaria is one the leading health problem of the Ethiopia. Previously, areas above 2,000 m elevation were considered as malaria free areas. However, the major malaria epidemics were seen in areas at an altitude up to 3,000 m above sea level These epidemics were due to climate and land-use changes (ecological changes) and still malaria is a growing health problem in highland parts of Ethiopia. This study aimed to investigate the species diversity..........
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Therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Chewaka District, Ethiopia
Background: The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool for supporting national treatment policies and practice.............
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Genetic diversity and genotype multiplicity of Plasmodium falciparum infection in patients with uncomplicated malaria in Chewaka district, Ethiopia
Background: Genetic diversity in Plasmodium falciparum poses a major threat to malaria control and elimination interventions. Characterization of the genetic diversity of P. falciparum strains can be used to assess intensity of parasite transmission and identify potential deficiencies.........
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Status of parasitological indicators and morbidity burden of onchocerciasis after years of successive implementation of mass distribution of ivermectin in selected communities …
Background: Control and elimination of onchocerciasis requires regular follow-up and evaluation of community directed treatment with ivermectin (CDTi) program implementation. This research was aimed to assess the epidemiological status of onchocerciasis in disease endemic communities of Asosa and Yeki districts ..........
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Comparison of infectivity of Plasmodium vivax to wild-caught and laboratory-adapted (colonized) Anopheles arabiensis mosquitoes in Ethiopia
Background: Mosquito-feeding assays that assess transmission of Plasmodium from man-to-mosquito typically use laboratory mosquito colonies. The microbiome and genetic.........
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Effects of land use on intermediate snail host fauna, abundance, distribution and cercariae infection rate in Omo-Gibe river basin, Ethiopia
Background: Land use and land cover change significantly affects biodiversity, abundance and distribution of intermediate snail host fauna. In Omo-Gibe river basin the extent of land-use change is high due to anthropogenic activities leading to habitat change of freshwater snail intermediate hosts..........
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Malaria in Migrant Agricultural Workers in Dangur District, Benishangul-gumuz, Ethiopia. Entomological Assessment of Malaria Transmission Risk
Background: Ethiopia has made great strides in malaria control. However, this progress has not been uniform and one concern has been reported high rates of malaria transmission in large agricultural development areas in western Ethiopia. Improved vector control is one way this transmission might........
Read More2020
Malaria Vector Survivorship Linked to Irrigated Sugarcane Plantation Scheme in Ethiopia
Background: To ensure food security, the sub-Saharan Africa has initiated massive water resource development projects in recent years. However, such environmental modi cations affect the survivorship and development of mosquitoes that are vectors of different diseases.........
Read More2020
Semi-high-throughput detection of P. falciparum and P. vivax oocysts in mosquitoes using bead-beating followed by CSP
Background: The malaria infection status of mosquitoes is commonly determined by microscopic detection of oocysts on the dissected mosquito midgut. This method is labor-intensive, does not allow processing..........
Read More2020