Publication 2017-2019

Evaluation of toxicity of clothianidin (neonicotinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabiensis …

Background: Insecticide-based interventions play an integral role in malaria vector control. However, the continued spread of insecticide resistance threatens to undermine progress made thus far and may ultimately lead to operational failure of current control measures..........

2019

Genome‐wide gene expression profiling reveals that cuticle alterations and P450 detoxification are associated with deltamethrin and DDT resistance in Anopheles arabiensis...…

Background: Vector control is the main intervention in malaria control and elimination strategies. However, the development of insecticide resistance is one of the major challenges for controlling malaria vectors. Anopheles..........

2019

Asymptomatic malaria in the clinical and public health context

Background: Historically, the global community has focused on the control of symptomatic malaria. However, interest in asymptomatic malaria has been growing, particularly in the context of malaria elimination Areas covered: We undertook a comprehensive PubMed literature review on asymptomatic malaria as it relates to detection and elimination with emphasis between 2014 and 2019. Diagnostic tools with a low limit of detection (LOD) have allowed us to develop.........

2019

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa

Background: Onchocerciasis (river blindness), caused by the filarial worm species Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public health and socioeconomic concern. It is transmitted through the bite.........

2019

Ten years malaria trend at Arjo-Didessa sugar development site and its vicinity, Southwest Ethiopia: a retrospective study

Background: The trend analysis of malaria data from health facilities is useful for understanding dynamics of malaria epidemiology and inform for future malaria control planning. Changes in clinical malaria characteristics like gender and age distribution are good indicators of declining malaria transmission. This study was conducted..........

2019

The effect of ivermectin® on fertility, fecundity and mortality of Anopheles arabiensis fed on treated men in Ethiopia

Background: Insecticide resistance is a growing threat to malaria vector control. Ivermectin, either administered to humans or animals, may represent an alternate strategy to reduce resistant mosquito populations The aim of this study was to assess the residual or delayed effect of administering a single........

2019

Environmental determinants of distribution of freshwater snails and trematode infection in the Omo Gibe River Basin, southwest Ethiopia

Background: Determination of infection rates of snail populations is one of the basic tools for epidemiological studies of snail borne diseases. In this study, we opted to determine the trematode infection of freshwater snails in the Omo-Gibe River Basin, southwest Ethiopia..........

2019

Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance

Background: Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen. PvDBP copy number has been recently shown to vary between P. vivax isolates in Sub-Saharan Africa. However, the extent of PvDBP copy number variation..........

2019

Prevalence and distribution of G6PD deficiency: implication for the use of primaquine in malaria treatment in Ethiopia

Background: G6PD enzyme deficiency is a common enzymatic X-linked disorder. Deficiency of the G6PD enzyme can cause free radical-mediated oxidative damage to red blood cells, leading to premature haemolysis. Treatment of Plasmodium vivax malaria with primaquine poses a potential........

2019

Evaluation of the performance of new sticky pots for outdoor resting malaria vector surveillance in western Kenya

Background: Surveillance of outdoor resting malaria vector populations is crucial to monitor possible changes in vector resting and feeding behaviour following the widespread use of indoor-based vector control interventions. However, it is seldom included in the routine vector surveillance system..........

2019

Bio-efficacy and physical integrity of piperonylbutoxide coated combination net (PermaNet® 3.0) against pyrethroid resistant population of Anopheles gambiae sl and Culex …

Background: PermaNet® 3.0 is a deltamethrin-treated combination long-lasting insecticidal net with the addition of synergist piperonylbutoxide (PBO) on its roof section. It is designed to overcome the challenge.........

2019

Technical efficiency of maternal and reproductive health services in public hospitals of Oromia regional state, Ethiopia

Background: As the Ethiopian health system faced critical resource constraints, wise use of the available health resources is a priority agenda. Therefore, our study aimed to assess technical efficiency of maternal and reproductive health services in public hospitals of Oromia regional state, Ethiopia. ........

2019

Distribution and trends of insecticide resistance in malaria vectors in Ethiopia (1986-2017): a review

Background: Malaria vector control intervention relies mainly on long-lasting insecticidal nets and indoor residual spraying. The distribution and frequency of insecticide resistance have increased dramatically and are now threatening the global success of the control program...........

2019

Performance evaluation of chemical insecticides used for indoor residual spraying against Anopheles arabiensis in Ethiopia

Background: Monitoring of the residual efficacy of insecticides is essential to determine the periods that they remain effective in interrupting malaria transmission and schedule when to re-spray..........

2019

Entomological surveillance in the context of malaria elimination in some selected sentiniel sites of Ethiopia

Background: Following the comandable progress made on malaria control programme so far, Ethiopia is persuing malaria elimination in 239 selected low transmission districts located in 6 different regions. Of these, 50 districts has been selected for elimination of local transmission of falciparum malaria based ........

2019

The effect of ivermectin

Background: Insecticide resistance is a growing threat to malaria vector control. Ivermectin, either administered to humans or animals, may represent an alternate strategy to reduce resistant mosquito populations. The aim of this study was to assess the residual or delayed effect of administering a single oral dose of ivermectin to humans on the survival, fecundity and fertility of Anopheles arabiensis in Ethiopia..........

2019

Bio-efficacy and physical integrity of piperonylbutoxide coated combination net (PermaNet).

Background: Both Anopheles gambiae sensu lato and Culex quinquefasciatus developed resistance against permethrin and deltamethrin. However, following pre-exposure to synergist PBO the susceptibility of mosquito population increased to both permethrin..........

2019

The Relative Contribution of Symptomatic and Asymptomatic Plasmodium vivax and Plasmodium falciparum Infections to the Infectious Reservoir in a Low …

Background: The majority of Plasmodium vivax and Plasmodium falciparum infections in low-endemic settings are asymptomatic. The relative contribution to the infectious reservoir of these infections compared to clinical malaria cases is currently unknown............

2018

Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa

Background: Parasite genetic diversity and multiplicity of infection (MOI) affect clinical outcomes, response to drug treatment and naturally-acquired or vaccine-induced immunity. Traditional methods often underestimate the frequency and diversity .........

2018

Detection of foci of residual malaria transmission through reactive case detection in Ethiopia

Background: Sub-microscopic and asymptomatic infections could be bottlenecks to malaria elimination efforts in Ethiopia. This study determined the prevalence of malaria, and individual and household-level factors associated with Plasmodium infections obtained following detection ........

2018

Habitat suitability modelling for predicting potential habitats of freshwater snail intermediate hosts in Omo-Gibe river basin, Southwest Ethiopia

Background: In spite of considerable progress made in the prevention and control of schistosomiasis and other snail-borne diseases, transmission has intensified in some endemic areas as a result of land-use and climate changes. We used decision tree models and multivariate............

2018

Quantifying malaria endemicity in Ethiopia through combined application of classical methods and enzyme-linked immunosorbent assay: an initial step for countries with low …

Background: In the context of reduced transmission of malaria, it is essential to re-evaluate and determine the level of transmission as it guides re-orientation of control measures which is appropriate to local.........

2018

BLOOD FEEDING BEHAVIOR OF MALARIA VECTORS IN THE ERA OF INTENSIVE VECTOR CONTROL EFFORTS IN WESTERN KENYA

Background: This research likely focuses on the feeding behavior of malaria-carrying mosquitoes in Western Kenya, especially in areas where intensive vector control measures have been implemented. By studying the feeding patterns of these mosquitoes, researchers can gain valuable insights ........

2018

A WHOLE TRANSCRIPTOMIC APPROACH TO CHARACTERIZE INSECTICIDE RESISTANCE MECHANISMS IN ANOPHELES ARABIENSIS (DIPTERA …

Background: This research likely uses a transcriptomic approach to study the molecular mechanisms underlying insecticide resistance in the malaria mosquito Anopheles arabiensis. By analyzing the entire set of genes expressed by resistant and susceptible mosquitoes,

2018

EVALUATION OF TOXICITY AND CROSS-RESISTANCE OF NOVEL CANDIDATE INSECTICIDES CLOTHIANIDIN, NEONICOTINOID, AND CHLORFENAPYR, PYRROLE, AGAINST WILD AND LABORATORY ANOPHELES …

Background: This research likely evaluates the toxicity and cross-resistance of two new insecticides, clothianidin (a neonicotinoid) and chlorfenapyr (a pyrrole), against wild and laboratory strains of Anopheles mosquitoes. The study may have aimed to assess the effectiveness of these new insecticides.........

2018

Indoor and outdoor malaria vector surveillance in western Kenya: implications for better understanding of residual transmission

Background: The widespread use of indoor-based malaria vector control interventions has been shown to alter the behavior of vectors in Africa. There is an increasing concern that such changes could sustain residual transmission. This study was .........

2017

Zooprophylaxis as a control strategy for malaria caused by the vector Anopheles arabiensis (Diptera: Culicidae): a systematic review

Background: Zooprophylaxis is the use of wild or domestic animals, which are not the reservoir host of a given disease, to divert the blood-seeking malaria vectors from human hosts. In this paper, we systematically reviewed zooprophylaxis to assess its efficacy as a malaria control strategy and to evaluate the possible methods of its application..........

2017

Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes

Background: Ethiopia is one of the few African countries where Plasmodium vivax is co-endemic with P. falciparum. Malaria transmission is seasonal and transmission intensity varies mainly by landscape and climate. Although the recent emergence of drug resistant parasites presents a major issue to malaria control in Ethiopia, little is known about the transmission pathways of parasite species and prevalence of resistant markers. This study used........

2017

Insecticide resistance in Anopheles arabiensis from Ethiopia (2012–2016): a nationwide study for insecticide resistance monitoring

Background: Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) remain the cornerstones of malaria vector control. However, the development of insecticide resistance and its implications for operational failure of preventative strategies are of concern..........

2017

Mapping insecticide resistance and characterization of resistance mechanisms in Anopheles arabiensis (Diptera: Culicidae) in Ethiopia

Background: The emergence and spread of insecticide resistance in the major African malaria vectors Anopheles gambiae (s.s.) and An. arabiensis may compromise the current vector control interventions and threatens the global malaria control and elimination efforts..........

2017

Household level spatio-temporal analysis of Plasmodium falciparum and Plasmodium vivax malaria in Ethiopia

Background: The global decline of malaria burden and goals for elimination has led to an increased interest in the fine-scale epidemiology of malaria. Micro-geographic heterogeneity of malaria infection could have implications for designing targeted small-area interventions........

2017

Determination of the residual efficacy of carbamate and organophosphate insecticides used for indoor residual spraying for malaria control in Ethiopia

Background: Indoor residual spraying is one of the key vector control interventions for malaria control in Ethiopia. As malaria transmission is seasonal in most parts of Ethiopia, a single round of spraying can usually provide effective protection against malaria, provided the..........

2017

Anopheline mosquitoes behaviour and entomological monitoring in southwestern Ethiopia

Background: Mosquito collection was carried out from each selected household in each of the nine selected study villages of Kersa district, using CDC light-traps and pyrethrum spray catches (PSCs) for seven months (June to December 2014). Mosquito count data were log transformed before analysis and the data were analyzed using SPSS software ..........

2017

Caretakers’ understanding of malaria, use of insecticide treated net and care seeking-behavior for febrile illness of their children in Ethiopia

Background: Local understandings of malaria and use of preventive measures-are critical factors in sustained control of malaria. This study assessed caretakers’ knowledge on malaria, use of Long Lasting Insecticide Treated Nets (LLINs) and care-seeking behavior for their children’s illness in different malaria transmission ........

2017

Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA …

Background: The malaria infection status of mosquitoes is commonly determined by microscopic detection of oocysts on the dissected mosquito midgut. This method is labour-intensive, does not allow processing of large........

2017

Diversity and composition of tropical butterflies along an Afromontane agricultural gradient in the Jimma Highlands, Ethiopia

Background: Afromontane landscapes are typically characterized by a mosaic of smallholder farms and the biodiversity impacts of these practices will vary in accordance to local management and landscape context. Here, we assess how tropical butterfly diversity is maintained ..........

2017

Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia

Background: This paper studies the effect of mosquito abundance and malaria incidence in the last 3 weeks, and their interaction, on the hazard of time to malaria in a previously studied cohort of children in Ethiopia. ........

2017

Relationship between exposure to malaria and haemoglobin level of children 2–9 years old in low malaria transmission settings

Background: In the context of reduced transmission of malaria, it is essential to examine the association between exposure to malaria and haemoglobin level. This study measured the Haemoglobin level of children 2–9 years of age and examined its association with malariometric indices A cross sectional study was conducted, during June 2016, on 763 children 2–9 years old,.........

2017

Piperonyl butoxide: an enhancing arsenal for an Adomant Foe

Background: Vector control using treated nets and recently industrially long lasting insecticidal nets (LLINs) have played a vital role in malaria control globally. The emergence of insecticides resistance among malaria vector against pyrethroids has raised a concern over achieved a milestone...... Read More

2017

DEVELOPMENT AND EVALUATION OF A NOVEL PIPE TRAP FOR OUTDOOR HOST-SEEKING MALARIA VECTOR SURVEILLANCE IN WESTERN KENYA

Background: This research likely describes the development and testing of a new type of trap designed to capture malaria-carrying mosquitoes outdoors. The trap is likely a modification of the standard CDC light trap, designed to be more effective in capturing host-seeking mosquitoes. ........

2017

EXPLORING THE ROLE OF PLASMODIUM VIVAX DUFFY BINDING PROTEIN 1 IN INVASION OF DUFFY-NULL AFRICANS

Background: This research likely focuses on the Plasmodium vivax Duffy Binding Protein 1 (PvDBP1) and its role in invading Duffy-negative individuals in Africa. While it's generally believed that individuals lacking the Duffy antigen are resistant to P. vivax infection, this research may explore potential mechanisms,.........

2017

ANALYSIS OF MULTIPLICITY OF ETHIOPIAN PLASMODIUM VIVAX INFECTIONS AND RELAPSE PATTERNS USING PVMSP1 AMPLICON DEEP SEQUENCING

Background: This research likely uses a technique called amplicon deep sequencing to analyze the genetic diversity of Plasmodium vivax parasites within individual infections. By studying the genetic variation of the parasite, researchers can gain insights into the transmission dynamics, drug...... Read More

2017

Protocol for Evaluation of the Efficacy of Long-Lasting Insecticide Treated Nets Under Field Conditions in Ethiopia, 2017

Background: The Global technical strategy for malaria 2016–2030, approved by the World Health Assembly in May 2015, set ambitious but achievable targets for 2030, including a reduction of at least 90% in global malaria incidence and mortality (WHO, 2015a). The World Health Organization (WHO) recommended malaria........

2017

INSECTICIDE RESISTANCE IN ANOPHELES GAMBIAE SL (DIPTERA: CULICIDAE) FROM ETHIOPIA (2012-2016): A NATIONWIDE STUDY FOR INSECTICIDE RESISTANCE MONITORING

Background: This research likely involves a nationwide study in Ethiopia to assess the level of insecticide resistance in the major malaria vector, Anopheles gambiae s.l.. By testing mosquito populations from different.........

2017

THE CONTRIBUTION OF SYMPTOMATIC AND ASYMPTOMATIC INFECTIONS TO THE INFECTIOUS RESERVOIR OF PLASMODIUM FALCIPARUM AND P. VIVAX IN ETHIOPIA

Background: This research likely investigates the role of both symptomatic and asymptomatic malaria infections in the transmission of Plasmodium falciparum and Plasmodium vivax in Ethiopia. By studying the prevalence of asymptomatic infections and their contribution ...... Read More

2017

AN OVERVIEW OF PLASMODIUM VIVAX GENOME STRUCTURE FROM A DUFFY NEGATIVE PATIENT AND ITS RELEVANCE TO ERYTHROCYTE INVASION

Background: This research likely focuses on understanding how Plasmodium vivax parasites, which typically require the Duffy antigen for invasion of red blood cells, can infect individuals who lack this antigen. By analyzing the genome of P. vivax parasites isolated ........

2017

Larvicidal effect of endod (Phytolacca dodecandra) seed products against Anopheles arabiensis (Diptera: Culicidae) in Ethiopia

Background: The purpose of the present study was to determine the larvicidal effect of 'Endod' (Phytolacca dodecandra) seed products on Anopheles arabiensis, in Ethiopia. Results: Experimental study was conducted using a total of 2400 third instars larvae of A. arabiensis.........

2017

Anopheline mosquitoes behaviour and entomological monitoring in southwestern Ethiopia.

Background: Despite a tremendous expansion in the financing and coverage of malaria control programmes, the disease continues to be a global health threat. This study was conducted to assess the entomological parameters of anopheline mosquitoes, viz. species composition, abundance, longevity, behaviour and infectivity rates in Kersa district,Jimma zone, southwestern Ethiopia....... Read More

2017

MOESM1 of Insecticide resistance in Anopheles arabiensis from Ethiopia (2012â 2016): a nationwide study for insecticide resistance monitoring

Background: Additional file 1: Tables S1. Summary of PMI-supported IRS activities in Ethiopia, 2008-2016. Table S2. Summary of insecticide resistance assays conducted per year in Ethiopia, 2012-2016. Table S3. Percentage corrected mortality (and numbers tested) of Anopheles arabiensis in WHO........

2017